Pleural tuberculosis (TB) remains difficult to diagnose. Tests measuring host biomarkers, such as adenosine deaminase (ADA) and unstimulated interferon-gamma, perform better than conventional microbiological tests for TB diagnosis using pleural […]
The diagnosis of pleural tuberculosis (TB) is problematic. The comparative performance of newer same-day tools for pleural TB, including Xpert MTB/RIF Ultra (ULTRA), has hitherto not been comprehensively studied. Adenosine […]
The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. The usefulness […]
Tuberculous pericarditis (TBP) is associated with high morbidity and mortality and is an important treatable cause of heart failure in developing countries. Tuberculous etiology of pericarditis is difficult to diagnose […]
The rapid diagnosis of tuberculous meningitis (TBM) is problematic. We found in 150 patients with suspected TBM that, similar to RD-1-specific quantitative cerebrospinal fluid (CSF) T-cell responses, unstimulated CSF gamma […]
We compared the diagnostic utility of unstimulated pleural IFN-γ levels with several pleural antigen-specific T-cell IGRAs (early secretory antigenic target-6 and culture filtrate protein-10 (T-SPOT.®TB, QuantiFERON®-TB Gold In-tube), purified protein […]
Project Overview Antrum Biotech, a healthcare innovations company dedicated to acquiring, developing and commercialising novel diagnostic platforms for infectious diseases, announces the launch of IRISATM-TB, an immuno-suspension assay for diagnosis […]
Background CNS infections are a leading cause of HIV-related deaths in sub-Saharan Africa, but causes and outcomes are poorly defined. We aimed to determine mortality and predictors of mortality in […]
TB is the most common cause of death in South Africa Researchers at the University of Cape Town have developed a landmark new rapid test which diagnoses various forms of Tuberculosis (TB) within hours. […]
TB meningitis is a major cause of death in Southern Africa. Early diagnosis is the key to improving the health outcomes of this disease, but the current diagnostic tests are […]
by 
